CNX-1351( CNX1351 | CNX 1351 | CNX-1351 )

Catalog No. M17234 CAS No. 1276105-89-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CNX-1351
Note

Research use only, not for human use.
Brief Description

CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.
Description

CNX-1351 is a selective covalent Inhibitor of PI3Kα. In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20 400 times less potent against β, γ, and δ. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα. CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α.
In Vitro

——
In Vivo

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Synonyms

CNX1351 | CNX 1351 | CNX-1351
Pathway

Others
Target

Other Targets
Recptor

PI3Kα
Research Area

Cancer
Indication

——

CAS Number

1276105-89-5
Formula Weight

573.71
Molecular Formula

C30H35N7O3S
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 21.8 mg/mL. 38.00 mM
SMILES

C1CN(CCN1C(=O)CCC(=O)C=C(C)C)Cc1cc2c(s1)c(nc(n2)c1cccc2c1cn[nH]2)N1CCOCC1
Chemical Name

1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione

1. Nacht M, et al. J Med Chem. 2013 Feb 14;56(3):712-21.

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