P7C3-A20

Research use only, not for human use.

P7C3 is a drug related to latrepirdine (dimebon), which has neuroprotective and proneurogenic effects, and may be potentially useful for the treatment of Alzheimer's disease and similar neurodegenerative disorders.

P7C3 is a drug related to latrepirdine (dimebon), which has neuroprotective and proneurogenic effects, and may be potentially useful for the treatment of Alzheimer's disease and similar neurodegenerative disorders.

Cell Viability Assay Cell Line:PC12 cells Concentration:10?μM, 20 μM, 40?μM, 60 μM, 80?μM, 100 μM Incubation Time:8 hours Result:Alleviated oxygen-glucose deprivation (OGD)-induced cytotoxicity in PC12 cells. Apoptosis Analysis Cell Line:PC12 cells Concentration:40?μM, 60 μM, 80?μM, 100 μM Incubation Time:8 hours Result:Alleviated oxygen-glucose deprivation (OGD)-induced apoptosis in PC12 cells.

Animal Model:Sprague-Dawley rats (200-250 g) induced hypoxic-ischemic (HI) injury Dosage:5?mg/kg, 10?mg/kg Administration:Intraperitoneal injection; daily; for 7 days Result:Reduced infarct volume; reversed cell loss in the cortex and hippocampus and improved motor function without causing neurotoxicity.

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Tyrosine Kinase

Src

Others

Neurological Disease

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1235481-90-9

506.2

C22H19Br2FN2O

>98% (HPLC)

DMSO : ≥ 100 mg/mL. 197.55 mM; H2O : < 0.1 mg/mL

COc1cccc(c1)NCC(Cn1c2c(cc(cc2)Br)c2c1ccc(c2)Br)F

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(-20℃)

With Ice Pack

≥ 2 years