Cart
sales@molnova.com
Skepinone-L
CAS No. 1221485-83-1
Skepinone-L( Skepinone-L )
Catalog No. M17201 CAS No. 1221485-83-1
Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 75 | In Stock |
|
| 2MG | 43 | In Stock |
|
| 5MG | 68 | In Stock |
|
| 10MG | 116 | In Stock |
|
| 25MG | 208 | In Stock |
|
| 50MG | 306 | In Stock |
|
| 100MG | 455 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSkepinone-L
-
NoteResearch use only, not for human use.
-
Brief DescriptionSkepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
-
DescriptionSkepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM).
-
In VitroSkepinone-L (CBS3830),the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity. Therefore, Skepinone-L (CBS3830) is a valuable probe for chem. biol. research, and it may foster the development of a unique class of kinase inhibitors.
-
In Vivo——
-
SynonymsSkepinone-L
-
PathwayMetabolic Enzyme/Protease
-
TargetDehydrogenase
-
Recptorp38α
-
Research AreaInflammation/Immunology
-
Indication——
Chemical Information
-
CAS Number1221485-83-1
-
Formula Weight425.42
-
Molecular FormulaC24H21F2NO4
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 50 mg/mL 117.53 mM; H2O : < 0.1 mg/mL
-
SMILESc12c(C(=O)c3c(CC1)ccc(c3)OC[C@@H](CO)O)ccc(c2)Nc1c(cc(cc1)F)F
-
Chemical Name2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Koeberle SC, et al. Nat Chem Biol. 2011, 8(2), 141-143.
molnova catalog
related products
-
GSK1940029
GSK1940029 is a stearoyl-coa desaturase (SCD) inhibitor.
-
DSM265
DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity (IC50: 8.9 nM).DSM265 inhibits the growth of Pf3D7 parasites and can be used for the treatment and prophylaxis of malaria infections.
-
IDH889
IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).
