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Skepinone-L
CAS No. 1221485-83-1
Skepinone-L( Skepinone-L )
Catalog No. M17201 CAS No. 1221485-83-1
Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 75 | In Stock |
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| 2MG | 43 | In Stock |
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| 5MG | 68 | In Stock |
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| 10MG | 116 | In Stock |
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| 25MG | 208 | In Stock |
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| 50MG | 306 | In Stock |
|
| 100MG | 455 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSkepinone-L
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NoteResearch use only, not for human use.
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Brief DescriptionSkepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
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DescriptionSkepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM).
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In VitroSkepinone-L (CBS3830),the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity. Therefore, Skepinone-L (CBS3830) is a valuable probe for chem. biol. research, and it may foster the development of a unique class of kinase inhibitors.
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In Vivo——
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SynonymsSkepinone-L
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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Recptorp38α
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1221485-83-1
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Formula Weight425.42
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Molecular FormulaC24H21F2NO4
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 50 mg/mL 117.53 mM; H2O : < 0.1 mg/mL
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SMILESc12c(C(=O)c3c(CC1)ccc(c3)OC[C@@H](CO)O)ccc(c2)Nc1c(cc(cc1)F)F
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Chemical Name2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Koeberle SC, et al. Nat Chem Biol. 2011, 8(2), 141-143.
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