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SPI 112

CAS No. 1051387-90-6

SPI 112( SPI-112 | SPI112 | SPI 112 )

Catalog No. M17127 CAS No. 1051387-90-6

SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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1 mL x 10 mM in DMSO 46 In Stock
10MG 41 In Stock
25MG 81 In Stock
50MG 140 In Stock
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Biological Information

  • Product Name
    SPI 112
  • Note
    Research use only, not for human use.
  • Brief Description
    SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.
  • Description
    SPI-112, the SPI-112 methyl ester analog was able to inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SPI-112 | SPI112 | SPI 112
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    SHP-2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1051387-90-6
  • Formula Weight
    468.45
  • Molecular Formula
    C22H17FN4O5S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (106.73 mM)
  • SMILES
    O=C(O)c1cccc(N/N=C/2\C(=O)Nc3c2cc(S(=O)(=O)NCc2ccc(F)cc2)cc3)c1
  • Chemical Name
    (Z)-3-(2-(5-(N-(4-Fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chen L, et al. Biochem Pharmacol. Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112 . 2010 Sep 15;80(6):801-10
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