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DAN 004
CAS No. ——
DAN 004( DAN004 | DAN-004 )
Catalog No. M17098 CAS No. ——
A small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 0.7 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameDAN 004
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 0.7 uM.
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DescriptionA small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 0.7 uM; potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity.
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In Vitro——
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In Vivo——
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SynonymsDAN004 | DAN-004
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight494.433
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Molecular FormulaC26H28BrN3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N[C@H](C(N(CCCN)CC1=CC=C(Br)C=C1)=O)CC2=CC=CC=C2)C3=CC=CC=C3
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Chemical Name(S)-N-(1-((3-aminopropyl)(4-bromobenzyl)amino)-1-oxo-3-phenylpropan-2-yl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5.
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