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MI-223
CAS No. 907166-59-0
MI-223( NSC 320223 )
Catalog No. M16518 CAS No. 907166-59-0
MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMI-223
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NoteResearch use only, not for human use.
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Brief DescriptionMI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM.
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DescriptionMI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents; not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress; exhibits a strong synergy against lung cancer in vivo combined with Olaparib.
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In Vitro——
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In Vivo——
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SynonymsNSC 320223
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research Area——
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Indication——
Chemical Information
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CAS Number907166-59-0
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Formula Weight419.865
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Molecular FormulaC23H18ClN3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1N(/N=C/C2=CC=CC(OCC)=C2O)C(C3=CC=CC=C3Cl)=NC4=C1C=CC=C4
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Chemical Name2-(2-chlorophenyl)-3-[[(Z)-(5-ethoxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]quinazolin-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chen G, et al. J Clin Invest. 2018 Jan 2;128(1):500-516.
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