CCR6 inhibitor 35( —— )

Catalog No. M17039 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CCR6 inhibitor 35
Note

Research use only, not for human use.
Brief Description

CCR6 inhibitor 35 is a potent and selective CCR6 inhibitor with IC50 of 6.0 nM (hCCR6).
Description

CCR6 inhibitor 35 is a potent and selective CCR6 inhibitor with IC50 of 6.0 nM (hCCR6); exhibits potent activity in the migration assay as well as the Gi signal assay with IC50 of <30 nM and 6 nM in human CCR6-transfected CHO cells, respectively, and displays high human CCR6 selectivity over human CCR1 and CCR7; potently inhibits CCR6-dependent cell migration and the increase in ERK phosphorylation in human primary cells.
In Vitro

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In Vivo

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Synonyms

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Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

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Indication

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CAS Number

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Formula Weight

504.528
Molecular Formula

C24H23F3N4O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

4-(4-(((1r,4r)-4-((5-(trifluoromethyl)pyridin-2-yl)amino)cyclohexyl)sulfonyl)phenyl)picolinamide

1. Tawaraishi T, et al. Bioorg Med Chem Lett. 2018 Jul 30. pii: S0960-894X(18)30637-1.

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