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CDP-840 hydrochloride
CAS No. ——
CDP-840 hydrochloride( CDP840 | L-765527 )
Catalog No. M16967 CAS No. ——
CDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCDP-840 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM.
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DescriptionCDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE 4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast; shows no effect for PDE-1, 2, 3, 5, and 7 (IC50>100 uM), exhibits no significant selectivity in inhibiting human recombinant isoenzymes PDE-4A, B, C or D and is equally active against the isoenzymes lacking UCR1 (PDE-4B2 and PDE-4D2); causes a dose-dependent reduction of IL-5-induced pleural eosinophilia in rats (ED50=0.03 mg/kg); prevents antigen-induced eosinophilia and bronchoconstriction; orally active.Asthma Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsCDP840 | L-765527
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight409.95
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Molecular FormulaC25H27NO2.HCl
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name4-[(2R)-2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-pyridine hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hughes B, et al. Br J Pharmacol. 1996 Jul;118(5):1183-91.
2. Holbrook M, et al. Br J Pharmacol. 1996 Jul;118(5):1192-200.
3. Perry MJ, et al. Cell Biochem Biophys. 1998;29(1-2):113-32.
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