Cart
sales@molnova.com
Tetomilast
CAS No. 145739-56-6
Tetomilast( OPC-6535 )
Catalog No. M11976 CAS No. 145739-56-6
Tetomilast (OPC-6535) is a superoxide anion production inhibitor that inhibits PDE4 and proinflammatory functions.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameTetomilast
-
NoteResearch use only, not for human use.
-
Brief DescriptionTetomilast (OPC-6535) is a superoxide anion production inhibitor that inhibits PDE4 and proinflammatory functions.
-
DescriptionTetomilast (OPC-6535) is a superoxide anion production inhibitor that inhibits PDE4 and proinflammatory functions of leukocytes including superoxide production and cytokine release; attenuates sepsis-induced acute lung injury.COPD Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsOPC-6535
-
PathwayAngiogenesis
-
TargetPDE
-
RecptorPDE
-
Research AreaInflammation/Immunology
-
IndicationCOPD
Chemical Information
-
CAS Number145739-56-6
-
Formula Weight370.42
-
Molecular FormulaC19H18N2O4S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(C1=NC(C2=CSC(C3=CC=C(OCC)C(OCC)=C3)=N2)=CC=C1)O
-
Chemical Name6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Schreiber S, et al. Gastroenterology. 2007 Jan;132(1):76-86.
2. Bloomfield GL, et al. J Surg Res. 1997 Sep;72(1):70-7.
3. Ejiri S, et al. Transplant Proc. 2000 Mar;32(2):318-21.
molnova catalog
related products
-
5,7-Diacetoxy-8-meth...
5,7-Diacetoxy-8-methoxyflavone is derived from the roots of Scutellaria baicalensis and inhibits cAMP phosphodiesterase.
-
THPP-1
THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).
-
Ensifentrine
Ensifentrine is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical development for the treatment of asthma and COPD and, potentially, cystic fibrosis.
