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Home - Products - Cell Cycle/DNA Damage - Potassium Channel - PF-04895162

PF-04895162

CAS No. ——

PF-04895162( ICA-105665 | PF 04895162 | ICA105665 | PF 4895162 )

Catalog No. M16958 CAS No. ——

PF-04895162 (ICA-105665, PF 4895162) is an orally available agonist of neuronal Kv7 potassium channel, opens Kv7.2/7.3 and Kv7.3/7.5 potassium channels.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-04895162
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-04895162 (ICA-105665, PF 4895162) is an orally available agonist of neuronal Kv7 potassium channel, opens Kv7.2/7.3 and Kv7.3/7.5 potassium channels.
  • Description
    PF-04895162 (ICA-105665, PF 4895162) is an orally available agonist of neuronal Kv7 potassium channel, opens Kv7.2/7.3 and Kv7.3/7.5 potassium channels, also known as KCNQ2/3 and KCNQ3/5 channels; ICA-105665 has demonstrated broad spectrum antiseizure activity in multiple animal models including maximal electroshock, 6 Hz seizures, pentylenetetrazole, and electrical kindling at doses from <1 to 5 mg/kg.Epilepsy Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ICA-105665 | PF 04895162 | ICA105665 | PF 4895162
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    355.345
  • Molecular Formula
    C19H15F2N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    N-(2-cyclopropyl-7-fluoro-4-oxoquinazolin-3(4H)-yl)-2-(4-fluorophenyl)ethanamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kasteleijn-Nolst Trenité DG, et al. Epilepsia. 2013 Aug;54(8):1437-43. 2. Aleo MD, et al. Pharmacol Res Perspect. 2019 Feb;7(1):e00467. 3. Bialer M, et al. Epilepsy Res. 2013 Jan;103(1):2-30. 4. Roeloffs R, et al. J Pharmacol Exp Ther. 2008 Sep;326(3):818-28.
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