Atpenin A5

Research use only, not for human use.

Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM). Atpenin A5 is also an effective mKATP channel agonist and cardioprotective agent.

Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM). Atpenin A5 is also an effective mKATP channel agonist and cardioprotective agent.(In Vitro):Atpenin A5 shows the inhibition profile for submitochondrial particles (SMPs), mitochondria, and cardiomyocytes, with IC50 values of 8.3 nM, 9.3 nM, and 8.5 nM, respectively. Atpenin A5 (AA5) is a potent and specific complex II inhibitor. Atpenin A5 (1 nM) also activates the mKATP channel and protects against simulated ischemia-reperfusion (IR) injury in isolated cardiomyocytes.(In Vivo):Atpenin A5 is a potent inhibitor of succinate dehydrogenase (SDH). SDH inhibition by Atpenin A5 promotes cardiomyocyte mitosis and regeneration in the postnatal heart after myocardial infarction (MI). Atpenin A5-injected (100 μg/kg) mice demonstrated myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls.

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Animal Model:Neonatal mice Dosage:100 μg/kg Administration:Injected daily Result:Demonstrated myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls.

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Cell Cycle/DNA Damage

Potassium Channel

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119509-24-9

366.24

C15H21Cl2NO5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (273.04 mM)

COc1[nH]c(=O)c(C(=O)[C@@H](C)C[C@H](C)[C@@H](Cl)CCl)c(O)c1OC

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(-20℃)

With Ice Pack

≥ 2 years