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Canrenone

CAS No. 976-71-6

Canrenone( Aldadiene | NSC 261713 | SC-9376 | SC-14266 )

Catalog No. M16883 CAS No. 976-71-6

A synthetic pregnadiene compound with anti-aldosterone activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Canrenone
  • Note
    Research use only, not for human use.
  • Brief Description
    A synthetic pregnadiene compound with anti-aldosterone activity.
  • Description
    A synthetic pregnadiene compound with anti-aldosterone activity.(In Vitro):Canrenone inhibits the production of eortieosterone, 18-hydroxydesoxyeortieosterone, 18-hydroxycorticosterone and aldosterone in a dose-dependent manner. Canrenone dose-dependently reduces platelet-derived growth factor–induced cell proliferation and motility. Canrenone inhibits the activity of the Na+/H+ exchanger 1 induced by platelet-derived growth factor.(In Vivo):Canrenone is the principal active metabolite of Spironolactone in the rat only for a limited period. During chronic treatment a difference developed between the effect of Spironolactone and Canrenone on the RAAS indicating a decrease in the anti-mineralocorticoid activity of Canrenone and an increase in the efficacy of Spironolactone.
  • In Vitro
    Canrenone inhibits the production of eortieosterone, 18-hydroxydesoxyeortieosterone, 18-hydroxycorticosterone and aldosterone in a dose-dependent manner. Canrenone dose-dependently reduces platelet-derived growth factor–induced cell proliferation and motility. Canrenone inhibits the activity of the Na+/H+ exchanger 1 induced by platelet-derived growth factor.
  • In Vivo
    Canrenone is the principal active metabolite of Spironolactone in the rat only for a limited period. During chronic treatment a difference developed between the effect of Spironolactone and Canrenone on the RAAS indicating a decrease in the anti-mineralocorticoid activity of Canrenone and an increase in the efficacy of Spironolactone.
  • Synonyms
    Aldadiene | NSC 261713 | SC-9376 | SC-14266
  • Pathway
    Endocrinology/Hormones
  • Target
    GR
  • Recptor
    Mineralocorticoid Receptor
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    976-71-6
  • Formula Weight
    340.46
  • Molecular Formula
    C22H28O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: > 10 mM
  • SMILES
    O=C1CC[C@]2(CO3)C4CC[C@]5(C3=O)[C@](O)(CCC(O)=O)CC[C@@]5([H])[C@]4([H])C=CC2=C1
  • Chemical Name
    3-((8R,10S,13R,14S,17R)-17-hydroxy-3,18-dioxo-2,3,8,9,11,12,14,15,16,17-decahydro-1H-10,13-(methanooxymethano)cyclopenta[a]phenanthren-17-yl)propanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Derosa G, et al. Ann Med. 2015 Feb;47(1):47-52.
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