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PI-3065
CAS No. 955977-50-1
PI-3065( PI3065 | PI 3065 )
Catalog No. M16821 CAS No. 955977-50-1
A potent inhibitor of PI3K p110δ with IC50/Ki values of 5/1.5 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 53 | In Stock |
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| 5MG | 87 | In Stock |
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| 10MG | 132 | In Stock |
|
| 25MG | 240 | In Stock |
|
| 50MG | 402 | In Stock |
|
| 100MG | 573 | In Stock |
|
| 500MG | 1197 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePI-3065
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NoteResearch use only, not for human use.
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Brief DescriptionA potent inhibitor of PI3K p110δ with IC50/Ki values of 5/1.5 nM respectively.
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DescriptionA potent inhibitor of PI3K p110δ with IC50/Ki values of 5/1.5 nM respectively; exhibits less potent activity against p110α, p110β, p110γ with IC50s of 910, 600, >10000 nM.
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In VitroPI-3065 exhibits no inhibition of the growth of 4T1 cells, which do not express detectable levels of p110δ.
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In VivoPI-3065 (75 mg/kg, p.o.) inhibits the growth of 4T1 tumours in the BALB/c mice without obvious body weight loss.
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SynonymsPI3065 | PI 3065
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorDNA-PK| mTOR| p110α| p110β| p110δ
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number955977-50-1
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Formula Weight506.638
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Molecular FormulaC27H31FN6OS
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Purity>98% (HPLC)
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SolubilityDMSO
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SMILESFC1=C(C2=NC(N3CCOCC3)=C4C(C=C(CN5CCN(CC6CC6)CC5)S4)=N2)C7=C(NC=C7)C=C1
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Chemical NameThieno[3,2-d]pyrimidine, 6-[[4-(cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ali K, et al. Nature. 2014 Jun 19;510(7505):407-11.
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