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PI3Kα-IN-4h
CAS No. 2100855-80-7
PI3Kα-IN-4h( —— )
Catalog No. M13328 CAS No. 2100855-80-7
PI3Kα-IN-1 is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePI3Kα-IN-4h
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NoteResearch use only, not for human use.
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Brief DescriptionPI3Kα-IN-1 is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively.
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DescriptionPI3Kα-IN-1 is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively; displays good selectivity for PI3Kα; demonstrates cytotoxicity in MCF7 cells, reasonable toxicity in MDA-MB-468 cells, good therapeutic index compared to normal skin fibroblasts, and acceptable in vitro ADME properties.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research Area——
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Indication——
Chemical Information
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CAS Number2100855-80-7
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Formula Weight483.532
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Molecular FormulaC26H25N7O3
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN-(4-(3-(4-(4-morpholinopyrido[3,2-d]pyrimidin-2-yl)phenyl)ureido)phenyl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Al-Ashmawy AAK, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3117-3122.
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