PI3Kα-IN-4h( —— )

Catalog No. M13328 CAS No. 2100855-80-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PI3Kα-IN-4h
Note

Research use only, not for human use.
Brief Description

PI3Kα-IN-1 is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively.
Description

PI3Kα-IN-1 is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively; displays good selectivity for PI3Kα; demonstrates cytotoxicity in MCF7 cells, reasonable toxicity in MDA-MB-468 cells, good therapeutic index compared to normal skin fibroblasts, and acceptable in vitro ADME properties.
In Vitro

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In Vivo

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Synonyms

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Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

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Indication

——

CAS Number

2100855-80-7
Formula Weight

483.532
Molecular Formula

C26H25N7O3
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

N-(4-(3-(4-(4-morpholinopyrido[3,2-d]pyrimidin-2-yl)phenyl)ureido)phenyl)acetamide

1. Al-Ashmawy AAK, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3117-3122.

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