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Liproxstatin-1
CAS No. 950455-15-9
Liproxstatin-1( Liproxstatin 1 )
Catalog No. M16796 CAS No. 950455-15-9
Liproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 125 | In Stock |
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| 25MG | 282 | In Stock |
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| 50MG | 450 | In Stock |
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| 100MG | 494 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
| 1 mL x 10 mM in DMSO | 73 | In Stock |
|
| 5MG | 73 | In Stock |
|
| 10MG | 125 | In Stock |
|
| 25MG | 243 | In Stock |
|
| 50MG | 382 | In Stock |
|
| 100MG | 485 | In Stock |
|
| 200MG | 698 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLiproxstatin-1
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NoteResearch use only, not for human use.
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Brief DescriptionLiproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4).
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DescriptionLiproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4), shows no activity on necroptosis; prevents BODIPY 581/591 C11 oxidation in Gpx4 / cells, does not interfere with other classical types of cell death, such as TNFα-induced apoptosis and H2O2-induced necrosis; suppresses ferroptosis in Gpx4(-/-) mice, and in a pre-clinical model of ischaemia/reperfusion-induced hepatic damage.
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In Vitro——
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In Vivo——
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SynonymsLiproxstatin 1
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PathwayApoptosis
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TargetFerroptosis
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RecptorFerroptosis
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number950455-15-9
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Formula Weight340.8499
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Molecular FormulaC19H21ClN4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 31 mg/mL
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SMILESClC1=CC(CNC(C23CCNCC2)=NC4=C(N3)C=CC=C4)=CC=C1
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Chemical NameSpiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine, N-[(3-chlorophenyl)methyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Friedmann Angeli JP, et al. Nat Cell Biol. 2014 Dec;16(12):1180-91.
2. Kim SE, et la. Nat Nanotechnol. 2016 Nov;11(11):977-985.
3. Zilka O, et al. ACS Cent Sci. 2017 Mar 22;3(3):232-243.
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