Cart
sales@molnova.com
Liproxstatin-1
CAS No. 950455-15-9
Liproxstatin-1( Liproxstatin 1 )
Catalog No. M16796 CAS No. 950455-15-9
Liproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
|
| 5MG | 73 | In Stock |
|
| 10MG | 125 | In Stock |
|
| 25MG | 282 | In Stock |
|
| 50MG | 450 | In Stock |
|
| 100MG | 494 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLiproxstatin-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionLiproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4).
-
DescriptionLiproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4), shows no activity on necroptosis; prevents BODIPY 581/591 C11 oxidation in Gpx4 / cells, does not interfere with other classical types of cell death, such as TNFα-induced apoptosis and H2O2-induced necrosis; suppresses ferroptosis in Gpx4(-/-) mice, and in a pre-clinical model of ischaemia/reperfusion-induced hepatic damage.
-
In Vitro——
-
In Vivo——
-
SynonymsLiproxstatin 1
-
PathwayApoptosis
-
TargetFerroptosis
-
RecptorFerroptosis
-
Research AreaOther Indications
-
Indication——
Chemical Information
-
CAS Number950455-15-9
-
Formula Weight340.8499
-
Molecular FormulaC19H21ClN4
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 31 mg/mL
-
SMILESClC1=CC(CNC(C23CCNCC2)=NC4=C(N3)C=CC=C4)=CC=C1
-
Chemical NameSpiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine, N-[(3-chlorophenyl)methyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Friedmann Angeli JP, et al. Nat Cell Biol. 2014 Dec;16(12):1180-91.
2. Kim SE, et la. Nat Nanotechnol. 2016 Nov;11(11):977-985.
3. Zilka O, et al. ACS Cent Sci. 2017 Mar 22;3(3):232-243.
molnova catalog
related products
-
MMRi62
MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53).
-
PRLX-93936 HCL
PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.
-
FINO2
FINO2 is a potent ferroptosis-inducing compound that inhibits GPX4 activity. It functions as a stable oxidant, effectively oxidizing ferrous iron and demonstrating stability across varying pH levels.
