BMS-457( BMS457 )

Catalog No. M16786 CAS No. 946594-19-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BMS-457
Note

Research use only, not for human use.
Brief Description

BMS-457 is a potent and selective CCR1 antagonist with binding IC50 of 0.8 nM.
Description

BMS-457 is a potent and selective CCR1 antagonist with binding IC50 of 0.8 nM, >1,000-fold selectivity against other CC family receptors; displays single-digit nanomolar inhibition of chemotaxis induced by a number of CCR1 ligands, including MIP-1α( IC50=2.1 nM), Leukotactin-1 (IC50=4.4 nM), RANTES (IC50=1.0 nM), MPIF-1 (IC50=2.7 nM), and HCC-1 (IC50=4.0 nM); blocks the ligand-stimulated upregulation of the β2-integrin CD11b in whole blood, with IC50 of 46 nM (MIP-1α) and 54 nM (LKN-1).
In Vitro

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In Vivo

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Synonyms

BMS457
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

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Indication

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CAS Number

946594-19-0
Formula Weight

451.004
Molecular Formula

C24H35ClN2O4
Purity

>98% (HPLC)
Solubility

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SMILES

O=C([C@H]1C[C@H](O)CC1)N[C@@H](C(N2CC(C)(C)[C@@](O)(C3=CC=C(Cl)C=C3)CC2)=O)C(C)C
Chemical Name

(1R,3R)-N-[(1R)-1-[[(4S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethyl-1-piperidinyl]carbonyl]-2-methylpropyl]-3-hydroxy-cyclopentanecarboxamide

1. Gardner DS, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3833-40.

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