Aumitin( Aumitin )

Catalog No. M16783 CAS No. 946293-78-3

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Product Name

Aumitin
Note

Research use only, not for human use.
Brief Description

Aumitin is a novel potent autophagy inhibitor with IC50 of 124 and 244 nM against starvation- and rapamycin- induced autophagy respectively.
Description

Aumitin is a novel potent autophagy inhibitor with IC50 of 124 and 244 nM against starvation- and rapamycin- induced autophagy respectively, targets mitochondrial complex I; inhibits LC3 lipidation, and p62 degradation by starvation- as well as rapamycin-induced autophagy dose-dependently in MCF7-LC3 cells, suggesting inhibition of autophagic flux; inhibits mitochondrial respiration by targeting complex I with IC50 of 0.11 uM in HeLa cells; Aumitin is a new tool compound for interrogating autophagy and mitochondrial respiration by means of complex I inhibition.
In Vitro

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In Vivo

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Synonyms

Aumitin
Pathway

Autophagy
Target

Autophagy
Recptor

Autophagy
Research Area

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Indication

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CAS Number

946293-78-3
Formula Weight

429.908
Molecular Formula

C24H20ClN5O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (232.61 mM)
SMILES

O=C(NC1=CC=C(NC2=NC(NC3=CC=CC=C3)=CC(C)=N2)C=C1)C4=CC=CC=C4Cl
Chemical Name

2-chloro-N-(4-((4-methyl-6-(phenylamino)pyrimidin-2-yl)amino)phenyl)benzamide

1. Robke L, et al. Chem Sci. 2018 Feb 26;9(11):3014-3022.

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