ROC-325( ROC 325 | ROC325 )

Catalog No. M12869 CAS No. 1859141-26-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ROC-325
Note

Research use only, not for human use.
Brief Description

ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy.
Description

ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy; exhibits superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in different cancer cell lines, including accumulation of autophagosomes with undegraded cargo, lysosomal deacidification, p62 stabilization, and disruption of autophagic flux; antagonizes RCC growth and survival in an ATG5/7-dependent manner, induces apoptosis and exhibited favorable selectivity; significantly more effective at inhibiting tumor progression than HCQ, and inhibited autophagy in vivo.
In Vitro

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In Vivo

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Synonyms

ROC 325 | ROC325
Pathway

Autophagy
Target

Autophagy
Recptor

Autophagy
Research Area

Cancer
Indication

——

CAS Number

1859141-26-6
Formula Weight

503.061
Molecular Formula

C28H27ClN4OS
Purity

>98% (HPLC)
Solubility

DMSO : 32 mg/mL 63.61 mM; H2O : < 0.1 mg/mL
SMILES

O=C1C2=C(C(C)=CC=C2NCCN(C)CCNC3=C(C=CC(Cl)=C4)C4=NC=C3)SC5=CC=CC=C51
Chemical Name

1-((2-((2-((7-chloroquinolin-4-yl)amino)ethyl)(methyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one

1. Carew JS, et al. Clin Cancer Res. 2017 Jun 1;23(11):2869-2879. 2. Carew JS, et al. Autophagy. 2017 Apr 3;13(4):765-766.

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