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AZD-1480
CAS No. 935666-88-9
AZD-1480( AZD1480 | AZD 1480 )
Catalog No. M16692 CAS No. 935666-88-9
A potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 51 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 77 | In Stock |
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| 25MG | 136 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD-1480
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM.
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DescriptionA potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM; demonstrates significant JAK2 selectivity over JAK3 and marginal selectivity over JAK1; blocks STAT3 phosphorylation in a panel of human solid tumor cell lines, potently inhibits the growth of the TEL-Jak2 cell line (GI50=60 nM); suppresses the growth of human solid tumor xenografts harboring persistent Stat3 activity.Liver Cancer Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsAZD1480 | AZD 1480
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PathwayAngiogenesis
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TargetJAK
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RecptorJAK2
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Research AreaCancer
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IndicationLiver Cancer
Chemical Information
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CAS Number935666-88-9
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Formula Weight348.766
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Molecular FormulaC14H14ClFN8
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=CC(NC2=NC(N[C@H](C3=NC=C(F)C=N3)C)=NC=C2Cl)=NN1
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Chemical Name2,4-Pyrimidinediamine, 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hedvat M, et al. Cancer Cell. 2009 Dec 8;16(6):487-97.
2. Ioannidis S, et al. J Med Chem. 2011 Jan 13;54(1):262-76.
3. Scuto A, et al. Leukemia. 2011 Mar;25(3):538-50.
4. Xin H, et al. Cancer Res. 2011 Nov 1;71(21):6601-10.
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