Cart
sales@molnova.com
IVA-337
CAS No. 927961-18-0
IVA-337( Lanifibranor | IVA337 )
Catalog No. M16646 CAS No. 927961-18-0
IVA-337 (Lanifibranor, IVA337)) is a potent, pan PPAR agonist with EC50 of 0.92 uM, 0.53 uM and 0.18 uM for human PPARα, PPARδ and PPARγ respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 31 | In Stock |
|
| 5MG | 50 | In Stock |
|
| 10MG | 87 | In Stock |
|
| 25MG | 176 | In Stock |
|
| 50MG | 322 | In Stock |
|
| 100MG | 485 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameIVA-337
-
NoteResearch use only, not for human use.
-
Brief DescriptionIVA-337 (Lanifibranor, IVA337)) is a potent, pan PPAR agonist with EC50 of 0.92 uM, 0.53 uM and 0.18 uM for human PPARα, PPARδ and PPARγ respectively.
-
DescriptionIVA-337 (Lanifibranor, IVA337)) is a potent, pan PPAR agonist with EC50 of 0.92 uM, 0.53 uM and 0.18 uM for human PPARα, PPARδ and PPARγ respectively; reduces skin fibrosis in the mouse, and suppresses inflammation in vivo.Steatohepatitis,Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsLanifibranor | IVA337
-
PathwayMetabolic Enzyme/Protease
-
TargetPPAR
-
RecptorPPAR
-
Research AreaOther Indications
-
IndicationSteatohepatitis
Chemical Information
-
CAS Number927961-18-0
-
Formula Weight434.909
-
Molecular FormulaC19H15ClN2O4S2
-
Purity>98% (HPLC)
-
SolubilityDMSO : 100 mg/mL 229.93 mM
-
SMILESO=C(O)CCCC(N1S(=O)(C2=CC=C3N=CSC3=C2)=O)=CC4=C1C=CC(Cl)=C4
-
Chemical Name4-(1-(1,3-Benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl)butanoic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ruzehaji N, et al. Ann Rheum Dis. 2016 Dec;75(12):2175-2183.
2. Avouac J, et al. Ann Rheum Dis. 2017 Aug 11. pii: annrheumdis-2016-210821.
molnova catalog
related products
-
Verbenalin
Verbenalin induces angiogenesis via a programmed PI3K/Akt/eNOS/VEGF signaling axis.
-
4'-Methoxychalcone
4'-Methoxychalcone with a variety of pharmacological activities such as anti-tumor and anti-inflammatory activities.
-
GW7647
GW7647 is a potent agonist of PPARα (EC50s: 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ, and PPARδ, respectively).GW7647 (50 nM) stimulates the PI3K phosphorylation followed by the Akt (Ser473) phosphorylation, which causes NOS1 phosphorylation increased the amounts of NO released in the stripped antral mucosa.
