BAY-4931( —— )

Catalog No. M36091 CAS No. 423150-91-8

BAY-4931 is a powerful, covalent, and selective inverse-agonist of PPARγ, exhibiting an IC50 value of 0.17 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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10MG	122	Get Quote
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Biological Information

Product Name

BAY-4931
Note

Research use only, not for human use.
Brief Description

BAY-4931 is a powerful, covalent, and selective inverse-agonist of PPARγ, exhibiting an IC50 value of 0.17 nM.
Description

BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC50 of 0.17 nM.
In Vitro

BAY-4931 (0-10 μM; 7 days) inhibits UM-UC-9 proliferation with an IC50 of 3.4 nM.BAY-4931 only inhibits CYP2C8 in CYP inhibition test.Cell Proliferation Assay Cell Line:UM-UC-9 cells Concentration:0-10 μM Incubation Time:7 days Result:Inhibited proliferation with an IC50 of 3.4 nM.
In Vivo

——
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

PPAR
Recptor

PPAR
Research Area

——
Indication

——

Chemical Information

CAS Number

423150-91-8
Formula Weight

421.83
Molecular Formula

C22H16ClN3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (296.33 mM; Ultrasonic (<70°C)
SMILES

N(C(=O)C1=CC(N(=O)=O)=CC=C1Cl)C=2C=C3C(OC(=N3)C4=CC=C(CC)C=C4)=CC2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Orsi DL, et al. Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069. J Med Chem. 2022 Nov 10;65(21):14843-14863.?

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