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USP8-IN-22d
CAS No. 924296-18-4
USP8-IN-22d( —— )
Catalog No. M16622 CAS No. 924296-18-4
A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.85 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 124 | In Stock |
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| 5MG | 112 | In Stock |
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| 10MG | 183 | In Stock |
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| 25MG | 352 | In Stock |
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| 50MG | 485 | In Stock |
|
| 100MG | 639 | In Stock |
|
| 200MG | 877 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUSP8-IN-22d
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.85 uM.
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DescriptionA potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.85 uM; shows no inhibitory activity for USP7 (IC50>100 uM).
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In VitroDUBs-IN-1 (22 d) is an active inhibitor of ubiquitin-specific proteases, with an IC50 of 0.85 μM for USP8. DUBs-IN-1 is inactive toward USP7 (IC50, >100 μM). DUBs-IN-1 and its analogs reduce the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50s ranging from 0.5 μM to 1.5?μM.
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number924296-18-4
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Formula Weight337.3342
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Molecular FormulaC20H11N5O
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Purity>98% (HPLC)
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SolubilityDMSO: 20 mg/mL
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SMILESC1=CC=C(C=C1)CON=C2C3=CC=CC=C3C4=NC(=C(N=C42)C#N)C#N
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Chemical Name9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(phenylmethoxy)imino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Colombo M, et al. ChemMedChem. 2010 Apr 6;5(4):552-8.
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