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AS1517499
CAS No. 919486-40-1
AS1517499( AS-1517499 | AS 1517499 )
Catalog No. M16599 CAS No. 919486-40-1
A novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
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| 5MG | 72 | In Stock |
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| 10MG | 110 | In Stock |
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| 25MG | 222 | In Stock |
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| 50MG | 356 | In Stock |
|
| 100MG | 444 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAS1517499
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay.
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DescriptionA novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay; inhibits IL-4-induced Th2 differentiation of mouse spleen T cells with IC50 of 2.3 nM, without influencing Th1 differentiation induced by IL-12; completely inhibits both the antigen-induced up-regulation of RhoA and BSM hyperresponsiveness, significantly inhibits antigen-induced production of IL-13 in mice.
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In Vitro——
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In Vivo——
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SynonymsAS-1517499 | AS 1517499
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT6
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number919486-40-1
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Formula Weight397.8581
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Molecular FormulaC20H20ClN5O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 35 mg/mL
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SMILESc1ccc(cc1)CNc2c(cnc(n2)NCCc3ccc(c(c3)Cl)O)C(=O)N
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Chemical Name5-Pyrimidinecarboxamide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nagashima S, et al. Bioorg Med Chem. 2007 Jan 15;15(2):1044-55.
2. Chiba Y, et al. Am J Respir Cell Mol Biol. 2009 Nov;41(5):516-24.
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