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AW-814141
CAS No. 905285-51-0
AW-814141( AW814141 )
Catalog No. M16508 CAS No. 905285-51-0
AW-814141 is a potent, selective and orally active inhibitor of p38 MAP kinase with IC50 of 100 nM/158 nM for p38α/p38β.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAW-814141
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NoteResearch use only, not for human use.
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Brief DescriptionAW-814141 is a potent, selective and orally active inhibitor of p38 MAP kinase with IC50 of 100 nM/158 nM for p38α/p38β.
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DescriptionAW-814141 is a potent, selective and orally active inhibitor of p38 MAP kinase with IC50 of 100 nM/158 nM for p38α/p38β; inhibits the release of TNF-alpha by lipopolysaccharide (LPS) treated human peripheral blood mononuclear cells with IC50 of 212 nM; inhibits paw swelling in CIA models.
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In Vitro——
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In Vivo——
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SynonymsAW814141
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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Recptorp38 MAPK
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Research Area——
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Indication——
Chemical Information
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CAS Number905285-51-0
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Formula Weight375.476
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Molecular FormulaC22H25N5O
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name2-(hexahydrocyclopenta(c)pyrrol-2-ylamino)-8-methyl-6-o-tolyl-8H-pyrido(2,3-d)pyrimidine-7-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chopra P, et al. Int Immunopharmacol. 2010 Apr;10(4):467-73.
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