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PFI-4
CAS No. 900305-37-5
PFI-4( PFI-4 | PFI 4 | PFI4 )
Catalog No. M16470 CAS No. 900305-37-5
A potent, selective inhibitor of the BRPF1 bromodomain with pIC50 of 7.3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 44 | In Stock |
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| 5MG | 37 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 116 | In Stock |
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| 50MG | 184 | In Stock |
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| 100MG | 305 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePFI-4
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective inhibitor of the BRPF1 bromodomain with pIC50 of 7.3.
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DescriptionA potent, selective inhibitor of the BRPF1 bromodomain with pIC50 of 7.3; exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4.
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In VitroPFI-4 (1.25 μM; 7 or 11 days) inhibits differentiation of human osteoclasts. Cell Viability Assay Cell Line:Osteoclasts Concentration:1.25 μM Incubation Time:7 or 11 days Result:Significantly reduces MMP9 secretion in osteoclasts.
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In Vivo——
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SynonymsPFI-4 | PFI 4 | PFI4
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBRPF1|BRPF2|BRPF3
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number900305-37-5
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Formula Weight380.4402
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Molecular FormulaC21H24N4O3
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Purity>98% (HPLC)
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SolubilityDMSO: 26 mg/mL
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SMILESO=C(NC1=C(N2CCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC
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Chemical NameBenzamide, N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Demont EH, et al. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5.
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