(R)-(-)-JQ1 Enantiomer( —— )

Catalog No. M11127 CAS No. 1268524-71-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

(R)-(-)-JQ1 Enantiomer
Note

Research use only, not for human use.
Brief Description

(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1, (+)-JQ-1 is a potent, specific BET bromodomain BRD4 inhibitor.
Description

(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1, (+)-JQ-1 is a potent, specific BET bromodomain BRD4 inhibitor, but (-)-JQ1 has no activity.
In Vitro

(R)-(-)-JQ1 Enantiomer shows no significant interaction with any bromodomain. Besides, (R)-(-)-JQ1 Enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC).
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

Cancer
Indication

——

CAS Number

1268524-71-5
Formula Weight

456.9882
Molecular Formula

C23H25ClN4O2S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
Chemical Name

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6R)-

1. Filippakopoulos P, et al. Nature. 2010 Dec 23;468(7327):1067-73.

Calculator

molnova catalog