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VU 0240551
CAS No. 893990-34-6
VU 0240551( VU0240551 )
Catalog No. M16441 CAS No. 893990-34-6
VU 0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 55 | Get Quote |
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| 5MG | 87 | Get Quote |
|
| 10MG | 133 | Get Quote |
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| 25MG | 282 | Get Quote |
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| 50MG | 530 | Get Quote |
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| 100MG | 763 | Get Quote |
|
| 200MG | 1035 | Get Quote |
|
| 500MG | 1521 | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameVU 0240551
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NoteResearch use only, not for human use.
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Brief DescriptionVU 0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells.
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DescriptionVU 0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells; displays >100-fold selectivity over NKCCl; also shows significant inhibition (>50% at 50 μM) of several GPCRs and key ion channels (hERG and L-Type Ca2+ channels).
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In VitroVU 0240551 reduces the P cell response to GABA in a concentration-dependent manner with 75 and 100 μM treatments causing a significant reduction in GABA-elicited hyperpolarization while 25 μM had no significant effect.
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In VivoVU 0240551 (10 μM) significantly blocks the chloride influx in cells from Eu rats but did not affect cells from SL rats.
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SynonymsVU0240551
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PathwayMembrane Transporter/Ion Channel
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TargetChloride Channel
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RecptorChloride Channel
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number893990-34-6
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Formula Weight342.43
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Molecular FormulaC16H14N4OS2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 50 mg/mL 146.01 mM; H2O : < 0.1 mg/mL
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SMILESO=C(NC1=NC(C)=CS1)CSC2=NN=C(C3=CC=CC=C3)C=C2
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Chemical NameN-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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