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Apcin
CAS No. 300815-04-7
Apcin( Apcin )
Catalog No. M13933 CAS No. 300815-04-7
Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 2MG | 54 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 136 | In Stock |
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| 25MG | 274 | In Stock |
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| 50MG | 462 | In Stock |
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| 100MG | 696 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameApcin
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NoteResearch use only, not for human use.
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Brief DescriptionApcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor.
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DescriptionApcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates; shows enhanced anti-MM activity combined with another APC/C inhibitor proTAME.
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In VitroApoptosis AnalysisCell Line:HMCLs LP-1 and RPMI-8226 cells Concentration:25, 50 μM Incubation Time:48 hoursResult:Had minor effects on multiple myeloma (MM) cells alone and significantly increased MM apoptosis combining with proTAME (6, 12 μM).Western Blot Analysis Cell Line:HeLa cells with Nocodazole (100?nM) Concentration:25?μM .Incubation Time:2-14 hours Result:Induced slippage more slowly, as indicated by Cdc27 dephosphorylation and a reduction in cyclin B1, securin and phosphoH3 levels beginning 4-6h after mitotic entry.
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In Vivo——
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SynonymsApcin
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PathwayProteasome/Ubiquitin
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TargetE3 Ubiquitin Ligase
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RecptorE3 Ubiquitin Ligase
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Research Area——
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Indication——
Chemical Information
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CAS Number300815-04-7
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Formula Weight438.65
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Molecular FormulaC13H14Cl3N7O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (284.97 mM)
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SMILESCC1=NC=C([N+]([O-])=O)N1CCOC(NC(C(Cl)(Cl)Cl)NC2=NC=CC=N2)=O
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Chemical Name[2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-carbamic acid, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sackton KL, et al. Nature. 2014 Oct 30;514(7524):646-9.
2. de Lange J, et al. Nat Commun. 2015 Oct 1;6:8399.
3. Lub S, et al. Oncotarget. 2016 Jan 26;7(4):4062-76.
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