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VA-012

CAS No. 885898-58-8

VA-012( VA012 )

Catalog No. M16412 CAS No. 885898-58-8

VA-012 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM) that exhibits dose-dependent potentiation of 5-HT efficacy with EC50 of 16 nM.

Purity : >98% (HPLC)

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Biological Information

Product Name

VA-012
Note

Research use only, not for human use.
Brief Description

VA-012 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM) that exhibits dose-dependent potentiation of 5-HT efficacy with EC50 of 16 nM.
Description

VA-012 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM) that exhibits dose-dependent potentiation of 5-HT efficacy with EC50 of 16 nM; shows no significant off-target activities, and low binding competition with serotonin or other orthosteric ligands; increases the anorectic effect combined with the SSRI sertraline; reduces food intake and body weight gain without causing CNS-related malaise.
In Vitro

——
In Vivo

——
Synonyms

VA012
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

885898-58-8
Formula Weight

313.4
Molecular Formula

C21H19N3
Purity

>98% (HPLC)
Solubility

——
SMILES

C1=CC=C(C=C1)CN2C=C(C3=CC=CC=C32)CNC4=CN=CC=C4
Chemical Name

1-(Phenylmethyl)-N-3-pyridinyl-1H-indole-3-methanamine

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. García Cárceles J, et al. J Med Chem. 2017 Nov 8. doi: 10.1021/acs.jmedchem.7b00994.

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