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DIF-3

CAS No. 113411-17-9

DIF-3( —— )

Catalog No. M35425 CAS No. 113411-17-9

DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 216 In Stock
5MG 235 In Stock
10MG 351 In Stock
25MG 588 In Stock
50MG 821 In Stock
100MG 1107 In Stock
200MG Get Quote In Stock
500MG 2260 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    DIF-3
  • Note
    Research use only, not for human use.
  • Brief Description
    DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins.
  • Description
    DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Wnt/beta/catenin
  • Recptor
    Wnt/beta-catenin | GSK-3 | CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    113411-17-9
  • Formula Weight
    272.72
  • Molecular Formula
    C13H17ClO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (366.68 mM; Ultrasonic )
  • SMILES
    CCCCCC(=O)c1c(O)cc(OC)c(Cl)c1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Naoya Kubokura , et al. Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo. J Pharmacol Sci. 2015 Apr;127(4):446-55.?
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