CE-326597( CE 326597 )

Catalog No. M16325 CAS No. 870615-40-0

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Product Name

CE-326597
Note

Research use only, not for human use.
Brief Description

A potent, selective agonist of the human and rat CCK1 receptor with Ki of 36 nM.
Description

A potent, selective agonist of the human and rat CCK1 receptor with Ki of 36 nM; significantly reduces food intake with minimal systemic exposure in rodents.Obesity Phase 2 Discontinued.
In Vitro

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In Vivo

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Synonyms

CE 326597
Pathway

GPCR/G Protein
Target

Cholecystokinin Receptor
Recptor

Cholecystokinin Receptor
Research Area

Metabolic Disease
Indication

Obesity

CAS Number

870615-40-0
Formula Weight

594.719
Molecular Formula

C37H34N6O2
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)N(C(CN(C1=O)C2=CC=CC=C2N3C(C4=CC=CC=C4)=NN=C3[C@@H]1CC5=CNC6=C5C=CC=C6)=O)CC7=CC=CC=C7
Chemical Name

(-)-4,5-Dihydro-4-(1H-indol-3-ylmethyl)-N-(1-methylethyl)-5-oxo-1-phenyl-N-(phenylmethyl)-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine-6-acetamide

1. Desai AJ, et al. J Med Chem. 2015 Dec 24;58(24):9562-77. 2. Elliott RL, et al. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6797-801.

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