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RX-3117
CAS No. 865838-26-2
RX-3117( TV-1360 | fluorocyclopentenylcytosine )
Catalog No. M16291 CAS No. 865838-26-2
RX-3117 (TV-1360, fluorocyclopentenylcytosine) is an orally available cytidine analog, nucleoside antimetabolite with potential antineoplastic activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 319 | In Stock |
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| 2MG | 212 | In Stock |
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| 5MG | 310 | In Stock |
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| 10MG | 444 | In Stock |
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| 25MG | 729 | In Stock |
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| 50MG | 995 | In Stock |
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| 100MG | 1349 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRX-3117
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NoteResearch use only, not for human use.
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Brief DescriptionRX-3117 (TV-1360, fluorocyclopentenylcytosine) is an orally available cytidine analog, nucleoside antimetabolite with potential antineoplastic activity.
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DescriptionRX-3117 (TV-1360, fluorocyclopentenylcytosine) is an orally available cytidine analog, nucleoside antimetabolite with potential antineoplastic activity; Fluorocyclopentenylcytosine (RX-3117) is activated by uridine-cytidine kinase 2 (UCK2); shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine.Chemotherapeutic Agents Phase 2 Clinical.
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In Vitro:Cell Viability Assay Cell Line:A549, SW1573 cells Concentration:11.7, 21 μM Incubation Time:48 h Result:Showed antiproliferative activity in A549 (63.7% cell growth), SW1573 cells (59% cell growth).Apoptosis Analysis Cell Line:A549, SW1573 NSCLC cells Concentration:5 μM for A549 cells, 10 μM for SW1573 cells Incubation Time:4 days Result:Induced cell cycle arrest at S phase and apoptosis.
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In VivoAnimal Model:Nude mice (human colon carcinoma HCT116 xenograft model)Dosage:2, 10 mg/kg Administration:I.p.; three times per week for five weeks Result:Caused significant inhibition of tumor growth at the doses of 2 and 10 mg/kg.
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SynonymsTV-1360 | fluorocyclopentenylcytosine
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PathwayCell Cycle/DNA Damage
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TargetNucleoside Antimetabolite/Analog
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RecptorNucleoside Antimetabolite/Analog
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Research AreaCancer
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IndicationChemotherapeutic
Chemical Information
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CAS Number865838-26-2
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Formula Weight257.22
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Molecular FormulaC10H12FN3O4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 50 mg/mL
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SMILESOCCC#CC1=NC(C2=CC=C(F)C=C2)=C(C3=CC=NC=C3)N1CCCC4=CC=CC=C4
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Chemical Name2(1H)-Pyrimidinone, 4-amino-1-[(1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Peters GJ, et al. Invest New Drugs. 2013 Dec;31(6):1444-57.
2. Yang MY, et al. Anticancer Res. 2014 Dec;34(12):6951-9.
3. Sarkisjan D, et al. PLoS One. 2016 Sep 9;11(9):e0162901.
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