Cart
sales@molnova.com
A-740003
CAS No. 861393-28-4
A-740003( A 740003 | A740003 )
Catalog No. M16238 CAS No. 861393-28-4
A-740003 (A740003) is a potent, selective, competitive P2X7 receptor antagonist with IC50 of 40 nM and 18 nM for hP2X7 and rP2X7, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 31 | In Stock |
|
| 10MG | 48 | In Stock |
|
| 50MG | 65 | In Stock |
|
| 100MG | 103 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameA-740003
-
NoteResearch use only, not for human use.
-
Brief DescriptionA-740003 (A740003) is a potent, selective, competitive P2X7 receptor antagonist with IC50 of 40 nM and 18 nM for hP2X7 and rP2X7, respectively.
-
DescriptionA-740003 (A740003) is a potent, selective, competitive P2X7 receptor antagonist with IC50 of 40 nM and 18 nM for hP2X7 and rP2X7, respectively; showed weak or no activity for other P2 receptors (IC50>10 uM); potently blocks agonist-evoked IL-1β release (IC50=156 nM) and pore formation (IC50=92 nM) in differentiated human THP-1 cells; produces dose-dependent antinociception in a spinal nerve ligation model (ED50=19 mg/kg i.p.) in the rat.Pain Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsA 740003 | A740003
-
PathwayMembrane Transporter/Ion Channel
-
TargetP2X Receptor
-
RecptorP2X7(Human)|ratP2X7receptor
-
Research AreaNeurological Disease
-
IndicationPain
Chemical Information
-
CAS Number861393-28-4
-
Formula Weight474.5548
-
Molecular FormulaC26H30N6O3
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C(NC(/N=C(NC#N)\NC1=C2C=CC=NC2=CC=C1)C(C)(C)C)CC3=CC=C(OC)C(OC)=C3
-
Chemical NameBenzeneacetamide, N-[1-[[(cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxy-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Honore P, et al. J Pharmacol Exp Ther. 2006 Dec;319(3):1376-85.
2. Morytko MJ, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2093-6.
3. King BF. Br J Pharmacol. 2007 Jul;151(5):565-7.
molnova catalog
related products
-
(E/Z)-Sivopixant
(E/Z)-Sivopixantis a potent P2X3 receptor antagonist, IC50 = 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.
-
α,β-Methylene ATP tr...
α,β-Methylene ATP trisodium, a phosphonate analog of ATP, is a selective P2X agonist that induces enhanced contraction of UBSM. α,β-Methylene ATP trisodium inhibits P2X1 and P2X3, but is inactive against P2X2, 4 and 7.
-
Eliapixant
Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough.
