Cart
sales@molnova.com
Cyclovirobuxin D
CAS No. 860-79-7
Cyclovirobuxin D( CVB-D | NSC 91722 )
Catalog No. M16237 CAS No. 860-79-7
Extracted from Buxus microphylla.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 35 | In Stock |
|
| 25MG | 53 | In Stock |
|
| 50MG | 73 | In Stock |
|
| 100MG | 105 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 254 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCyclovirobuxin D
-
NoteResearch use only, not for human use.
-
Brief DescriptionExtracted from Buxus microphylla.
-
DescriptionExtracted from Buxus microphylla;Suitability:Chloroform,methanol and ethanol;Store the product in sealed,cool and dry condition.
-
In VitroCyclovirobuxine D (0-240 μM ;24-72 hours) shows a concentration- and time-dependent reduced cell viability after CVB-D treatment, only 10% MGC-803 cells and 20% MKN28 cells are alive at 72 h after treatment with 240 μM.Cyclovirobuxine D (0-120 μM; 48 hours) arrests the cell cycle of gastric cancer cells at S phase in a concentration-dependent manner.Cyclovirobuxine D (0-120 μM; 48 hours) leads to apoptosis in gastric cancer cells in a concentration-dependent manner, especially early stage apoptosis.Cyclovirobuxine D (0-120 μM; 48 hours) causes apoptosis via up-regulation of the apoptosis- related proteins, cleaved Caspase-3 and ratio of Bax/Bcl-2, in gastric cancer cells. Cell Viability Assay Cell Line:MGC-803 and MKN28 cells Concentration:0, 30, 60, 120 and 240 μM Incubation Time:24, 48, 72 hours Result:Reduced Cell Viability and Colony Formation Ability of Gastric Cancer Cells Cell Cycle Analysis Cell Line:MGC-803 and MKN28 cells Concentration:0, 30, 60, and 120 μM Incubation Time:48 hours Result:Arrested cell cycle progressions of MGC-803 and MKN28 cells.Apoptosis Analysis Cell Line:MGC-803 and MKN28 cells Concentration:0, 30, 60, and 120 μM Incubation Time:48 hours Result:Induced apoptosis of MGC-803 and MKN28 cells.Western Blot Analysis Cell Line:MGC-803 and MKN28 cells Concentration:0, 30, 60, and 120 μM Incubation Time:48 hoursResult:Up-regulated cleaved Caspase-3 and Bax and decreased the expression of Bcl-2 expression.
-
In Vivo——
-
SynonymsCVB-D | NSC 91722
-
PathwayOthers
-
TargetOther Targets
-
RecptorOthers
-
Research AreaOther Indications
-
Indication——
Chemical Information
-
CAS Number860-79-7
-
Formula Weight402.66
-
Molecular FormulaC26H46N2O
-
Purity>98% (HPLC)
-
SolubilityEthanol: 20 mg/mL (49.66 mM)
-
SMILESC[C@H](NC)[C@H]1[C@H](O)C[C@@]2(C)[C@]3([H])CC[C@@]4([H])C(C)(C)[C@@H](NC)CC[C@]4(C5)[C@@]35CC[C@]12C
-
Chemical Name9,19-Cyclo-5-alpha,9-beta-pregnan-16-alpha-ol, 4,4,14-trimethyl-3-beta,20-alpha-bis(methylamino)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
P110
Dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro. Reduces programmed cell death and improves cell viability by protecting mitochondrial integrity. Reduces mitochondrial fragmentation and mitochondrial ROS production in mouse model of Parkinson's disease. Cell permeable.
-
Lucigenin
Lucigenin (L-6868) is a chemiluminescent probe used to indicate the presence of endogenously generated superoxide anion radicals in cells.
-
(Z)-Indirubin
(Z)-Indirubin is an isomer of Indirubin. Indirubin is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia.
