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UCPH-101
CAS No. 1118460-77-7
UCPH-101( UCPH-101, UCPH 101, UCPH101 )
Catalog No. M17146 CAS No. 1118460-77-7
UCPH-101 is an inhibitor of excitatory amino acid transporter subtype 1 (EAAT1) with an IC50 of 0.66 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 145 | In Stock |
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| 2MG | 69 | In Stock |
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| 5MG | 132 | In Stock |
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| 10MG | 215 | In Stock |
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| 25MG | 432 | In Stock |
|
| 50MG | 677 | In Stock |
|
| 100MG | 986 | In Stock |
|
| 200MG | 1330 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUCPH-101
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NoteResearch use only, not for human use.
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Brief DescriptionUCPH-101 is an inhibitor of excitatory amino acid transporter subtype 1 (EAAT1) with an IC50 of 0.66 μM.
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DescriptionUCPH-101 is a selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor.
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In VitroUCPH-101 and UCPH-102 inhibit EAAT1 anion currents in a concentration-dependent manner, with KD values of 0.34±0.03 μM (Hill=1.3±0.13, n≥9) for UCPH-101 and 0.17±0.02 μM (Hill=0.97±0.11, n≥7) for UCPH-102. A small but significant decrease in the total expression levels of both HA-EAAT1 and HA-GLAST is observed in cells preincubated with 100 μM UCPH-101 (p=0.048).
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In Vivo——
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SynonymsUCPH-101, UCPH 101, UCPH101
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PathwayOthers
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TargetOther Targets
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RecptorEAAT1
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number1118460-77-7
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Formula Weight422.48
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Molecular FormulaC27H22N2O3
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 110 mg/mL 260.37 mM
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SMILESCOC1=CC=C(C=C1)C2C(=C(OC3=C2C(=O)CC(C3)C4=CC=CC5=CC=CC=C54)N)C#N
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Chemical Name2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Abrahamsen B, et al. J Neurosci. 2013 Jan 16;33(3):1068-87.
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