MARPIN( —— )

Catalog No. M16161 CAS No. 848675-17-2

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Product Name

MARPIN
Note

Research use only, not for human use.
Brief Description

MARPIN is a novel ATR-Chk1 pathway inhibitor that inhibits hydroxyurea (HU)-induced phosphorylation of Ser345 on Chk1 with IC50 of 7.7 uM.
Description

MARPIN is a novel ATR-Chk1 pathway inhibitor that inhibits hydroxyurea (HU)-induced phosphorylation of Ser345 on Chk1 with IC50 of 7.7 uM; inhibits ATR-selective phosphorylation and sensitizes p53-deficient cancer cells to DNA-damaging agents; does not inhibit ATR catalytic activity in vitro, but acts in a mechanistically distinct manner to disable ATR-Chk1 function; shows synergistic effect with cisplatin in xenograft model.
In Vitro

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In Vivo

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Synonyms

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Pathway

Angiogenesis
Target

Chk
Recptor

Chk
Research Area

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Indication

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CAS Number

848675-17-2
Formula Weight

405.425
Molecular Formula

C24H20FNO4
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

Methyl (1R,6aR)-2-benzoyl-1-(4-fluorobenzyl)-6-methylene-5-oxo-1,2,3,5,6,6a-hexahydrocyclopenta[c]pyrrole-1-carboxylate

1. Huryn DM, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6757-62. 2. Kawasumi M, et al. Cancer Res. 2014 Dec 15;74(24):7534-45.

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