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NSC-109555 ditosylate
CAS No. 66748-43-4
NSC-109555 ditosylate( DDUG | NSC109555 | NSC 109555 )
Catalog No. M15549 CAS No. 66748-43-4
A potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameNSC-109555 ditosylate
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 uM.
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DescriptionA potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 uM; displays no effect on a range of other kinases including Chk1 (IC50>10 uM); inhibits histone H1 phosphorylation (IC50=0.24 uM) and attenuates mitochondrial ATP synthesis; exhibits antiproliferative activity in a number of leukemias in vivo.
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In Vitro——
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In Vivo——
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SynonymsDDUG | NSC109555 | NSC 109555
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PathwayAngiogenesis
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TargetChk
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RecptorChk
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Research Area——
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Indication——
Chemical Information
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CAS Number66748-43-4
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Formula Weight752.86
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Molecular FormulaC19H24N10O.2C7H8O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=CC=C(/C(C)=N/N=C(N)/N)C=C1)NC2=CC=C(/C(C)=N/N=C(N)/N)C=C2.OS(=O)(C3=CC=C(C)C=C3)=O.OS(=O)(C4=CC=C(C)C=C4)=O
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Chemical Name4,4'-diacetyldiphenylurea bis(guanylhydrazone) ditosylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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CCT241533
A potent and selective ATP-competitive inhibitor of CHK2 K5777:N5777with IC50 of 3 nM.
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VRX-0466617
A potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM; shows no inhibitory effect on Chk1 (>100 uM).
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SAR-020106
SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3 nmol/L on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion.
