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Home - Products - Metabolic Enzyme/Protease - Aminopeptidase - JNJ-26993135

JNJ-26993135

CAS No. 841202-16-2

JNJ-26993135( JNJ26993135 )

Catalog No. M16124 CAS No. 841202-16-2

JNJ-26993135 is a potent, selective leukotriene A4 hydrolase (LTA4H) inhibitor.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    JNJ-26993135
  • Note
    Research use only, not for human use.
  • Brief Description
    JNJ-26993135 is a potent, selective leukotriene A4 hydrolase (LTA4H) inhibitor.
  • Description
    JNJ-26993135 is a potent, selective leukotriene A4 hydrolase (LTA4H) inhibitor, inhibits both the epoxide hydrolase and aminopeptidase activities of recombinant human LTA4H with IC50 of 10 nM; has no significant effects on LTC4, lipoxin A4, or PGE2 production; dose-dependently inhibits ex vivo LTB(4) production in blood (IC50=339 nM), in parallel with dose-dependent inhibition of neutrophil influx (ED50, 1-3 mg/kg) and ear edema in murine model of arachidonic acid-induced ear inflammation; selectively inhibited LTB(4) production, without affecting cysteinyl leukotriene production.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    JNJ26993135
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Aminopeptidase
  • Recptor
    Aminopeptidase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    841202-16-2
  • Formula Weight
    368.451
  • Molecular Formula
    C20H20N2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1CCN(CC2=CC=C(OC3=NC4=CC=CC=C4S3)C=C2)CC1)O
  • Chemical Name
    1-[4-(benzothiazol-2-yloxy)-benzyl]-piperidine-4-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rao NL, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1154-60. 2. Whittle BJ, et al. Br J Pharmacol. 2008 Mar;153(5):983-91.
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