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LAF389
CAS No. 270902-51-7
LAF389( LAF-389 | LAF 389 )
Catalog No. M13827 CAS No. 270902-51-7
LAF389 is a potent methionine aminopeptidase (MetAP) inhibitor with IC50 of 800 nM for MetAP-2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameLAF389
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NoteResearch use only, not for human use.
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Brief DescriptionLAF389 is a potent methionine aminopeptidase (MetAP) inhibitor with IC50 of 800 nM for MetAP-2.
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DescriptionLAF389 is a potent methionine aminopeptidase (MetAP) inhibitor with IC50 of 800 nM for MetAP-2, inhibits both MetAp1 and 2, potently inhibits HUVEC proliferation with IC50 of 20 nM; demonstrates both antiproliferative and antiangiogenetic properties, and preclinical investigations showed a broad antitumour activity.Blood CancerPhase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsLAF-389 | LAF 389
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PathwayMetabolic Enzyme/Protease
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TargetAminopeptidase
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RecptorAminopeptidase
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number270902-51-7
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Formula Weight498.617
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Molecular FormulaC25H42N2O8
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)(C)C=CC(C(C(C(C(=O)NC1CCC(CNC1=O)OC(=O)C2CCCCC2)OC)O)O)O
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Chemical Name[(3R,6S)-7-oxo-6-[[(E,2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enoyl]amino]azepan-3-yl] cyclohexanecarboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kinder FR Jr, et al. J Med Chem. 2001 Oct 25;44(22):3692-9.
2. Towbin H, et al. J Biol Chem. 2003 Dec 26;278(52):52964-71.
3. Kim S, et al. Cancer Res. 2004 May 1;64(9):2984-7.
4. Dumez H, et al. Anticancer Drugs. 2007 Feb;18(2):219-25.
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