Delapril?Hydrochloride

Research use only, not for human use.

Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid.

Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion.(In Vivo):Delapril (3 mg/kg; administered orally for 2 weeks) exerts potent ACE inhibitory activity in spontaneously hypertensive rat (SHR) .Delapril (1-10 mg/kg; orally) exerts a marked and long-lasting antihypertensive action in various experimental models of hypertension.

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Delapril (3 mg/kg; administered orally for 2 weeks) exerts potent ACE inhibitory activity in spontaneously hypertensive rat (SHR) .Delapril (1-10 mg/kg; orally) exerts a marked and long-lasting antihypertensive action in various experimental models of hypertension. Animal Model:SHR Dosage:3 mg/kg Administration:Administered orally; 2 weeks Result:Exerted potent ACE inhibitory activity.Animal Model:2-kidney, 1-clip hypertensive Rats, Dogs, and SHR Dosage:1-10 mg/kg.Administration:Oral Result:Exerted a marked and long-lasting antihypertensive action.

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Endocrinology/Hormones

RAAS

ACE

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83435-67-0

489

C26H33ClN2O5

>98% (HPLC)

Soluble in DMSO

CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N(CC(=O)O)C2CC3=CC=CC=C3C2.Cl

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(-20℃)

With Ice Pack

≥ 2 years