L162389( —— )

Catalog No. M32992 CAS No. 169281-53-2

L162389 is an orally active and potent angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor subtypes that stimulates the conversion of phosphatidylinositol.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

L162389
Note

Research use only, not for human use.
Brief Description

L162389 is an orally active and potent angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor subtypes that stimulates the conversion of phosphatidylinositol.
Description

L162389 is a potent antagonist of angiotensin AT1 receptor with Ki of 28 nM.
In Vitro

L-162,389 stimulates phosphatidylinositol turnover, albeit only to a small percentage of the angiotensin response. L-162,389 acts as angiotensin antagonist with IC50 value of 105 nM.
In Vivo

——
Synonyms

——
Pathway

Endocrinology/Hormones
Target

RAAS
Recptor

RAAS
Research Area

——
Indication

——

Chemical Information

CAS Number

169281-53-2
Formula Weight

562.72
Molecular Formula

C31H38N4O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(OCCCC)NS(=O)(=O)C=1C=CC(=CC1C2=CC=C(C=C2)CN3C4=NC(=CC(=C4N=C3CC)C)C)CCC
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Perlman S, et al. Dual agonistic and antagonistic property of nonpeptide angiotensin AT1 ligands: susceptibility to receptor mutations. Mol Pharmacol. 1997 Feb;51(2):301-11.?

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