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Atomoxetine hydrochloride

CAS No. 82248-59-7

Atomoxetine hydrochloride( Tomoxetine | LY-139603 )

Catalog No. M16057 CAS No. 82248-59-7

A selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM; shows weak affinity for 5-HT and dopamine transporters with IC50 of 77 and 1,451 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Atomoxetine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM; shows weak affinity for 5-HT and dopamine transporters with IC50 of 77 and 1,451 nM, respectively.
  • Description
    A selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM; shows weak affinity for 5-HT and dopamine transporters with IC50 of 77 and 1,451 nM, respectively; approved for the treatment of attention deficit hyperactivity disorder (ADHD).Other Indication Approved.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Sprague-Dawley rats Dosage:0.3, 1 and 3 mg/kg Administration:Intraperitoneal injection; for 4 hours Result:Increased the number of cells expressing Fos-like immunoreactivity in PFC 3.7-fold and increased extracellular norepinephrine and dopamine by 3-fold.Animal Model:Spontaneously hypertensive rat (SHR) Dosage:0.1, 0.3, 1.25 and 5.0 mg/kg Administration:Intraperitoneal injection and oral administration; for 14 days Result:Had non-impact on the measurement of motor activity.
  • Synonyms
    Tomoxetine | LY-139603
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Monoamine Transporter
  • Recptor
    5-HT|DAtransporter|Norepinephrine(NE)transporter
  • Research Area
    Neurological Disease
  • Indication
    Parkinson Disease

Chemical Information

  • CAS Number
    82248-59-7
  • Formula Weight
    291.8157
  • Molecular Formula
    C17H22ClNO
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC1=CC=CC=C1O[C@@H](C2=CC=CC=C2)CCNC.[H]Cl
  • Chemical Name
    Benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, hydrochloride (1:1), (γR)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bymaster FP, et al. Neuropsychopharmacology. 2002 Nov;27(5):699-711. 2. Sauer JM, et al. Clin Pharmacokinet. 2005;44(6):571-90. 3. Passamonti L, et al. Psychopharmacology (Berl). 2017 Aug;234(15):2289-2297.
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