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Loratadine

CAS No. 79794-75-5

Loratadine( Loratidine | SCH-29851 )

Catalog No. M15987 CAS No. 79794-75-5

A tricyclic antihistamine that acts as a selective inverse agonist of peripheral histamine H1-receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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1 mL x 10 mM in DMSO 28 In Stock
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200MG 28 In Stock
500MG 38 In Stock
1G 52 In Stock
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Biological Information

  • Product Name
    Loratadine
  • Note
    Research use only, not for human use.
  • Brief Description
    A tricyclic antihistamine that acts as a selective inverse agonist of peripheral histamine H1-receptors.
  • Description
    A tricyclic antihistamine that acts as a selective inverse agonist of peripheral histamine H1-receptors.Allergy Approved(In Vitro):Loratadine is an antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells.
  • In Vitro
    Loratadine is an antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells.
  • In Vivo
    ——
  • Synonyms
    Loratidine | SCH-29851
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    B(0)AT2
  • Research Area
    Inflammation/Immunology
  • Indication
    Allergy

Chemical Information

  • CAS Number
    79794-75-5
  • Formula Weight
    382.8832
  • Molecular Formula
    C22H23ClN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
  • Chemical Name
    1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Devillier P, et al. Clin Pharmacokinet. 2008;47(4):217-30. 2. Barnett A, et al. Agents Actions. 1984 Jun;14(5-6):590-7. 3. Roman IJ, et al. Clin Rev Allergy. 1993 Spring;11(1):89-110.
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