Imipenem monohydrate( N-Formimidoyl Thienamycin )

Catalog No. M15841 CAS No. 74431-23-5

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HNMR

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Product Name

Imipenem monohydrate
Note

Research use only, not for human use.
Brief Description

Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria.
Description

Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
In Vitro

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In Vivo

Imipenem monohydrate (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent.Pharmacokinetic Parameters of Imipenem monohydrate in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single). Animal Model:Neutropenic mouse model of biofilm lung infection Dosage:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg Administration:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single Result:Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.
Synonyms

N-Formimidoyl Thienamycin
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

PBPs| β-Lactamase
Research Area

Infection
Indication

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1.Pichardo C, et al. Antimicrob Agents ChemOthers. 2005 Aug;49(8):3311-6.

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