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NITD-564

CAS No. 1614262-75-7

NITD-564( NITD564 )

Catalog No. M12348 CAS No. 1614262-75-7

NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

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Biological Information

Product Name

NITD-564
Note

Research use only, not for human use.
Brief Description

NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb.
Description

NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb; binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.
In Vitro

——
In Vivo

——
Synonyms

NITD564
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

Chemical Information

CAS Number

1614262-75-7
Formula Weight

283.371
Molecular Formula

C18H21NO2
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

6-(cyclohexylmethyl)-4-hydroxy-3-phenylpyridin-2(1H)-one

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3.

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