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NITD-564
CAS No. 1614262-75-7
NITD-564( NITD564 )
Catalog No. M12348 CAS No. 1614262-75-7
NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameNITD-564
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NoteResearch use only, not for human use.
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Brief DescriptionNITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb.
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DescriptionNITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb; binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.
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In Vitro——
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In Vivo——
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SynonymsNITD564
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number1614262-75-7
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Formula Weight283.371
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Molecular FormulaC18H21NO2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name6-(cyclohexylmethyl)-4-hydroxy-3-phenylpyridin-2(1H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3.
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