Sodium etidronate

CAS No. 7414-83-7

Sodium etidronate( Etidronic Acid | Didronel | HEDP | Hydroxyethylidene Diphosphonic Acid )

Catalog No. M15829 CAS No. 7414-83-7

A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Sodium etidronate
  • Note
    Research use only, not for human use.
  • Brief Description
    A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
  • Description
    A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover. (In Vitro):Etidronic acid (Etidronate) (10 mM, 24 h) disodium shows cytotoxicity, causes a decrease in the S-phase population and an increase in the G2/M population, induces p53 mutation in MCF-7 cells.Etidronic acid (100 nM, 24 h) disodium induces osteoclast apoptosis, which displays characteristics of apoptosis, including chromatin condensation and changed cellular and nuclear morphology, detected by fluorescence microscopy.
  • In Vitro
    Etidronic acid (Etidronate) (10 mM, 24 h) disodium shows cytotoxicity, causes a decrease in the S-phase population and an increase in the G2/M population, induces p53 mutation in MCF-7 cells.Etidronic acid (100 nM, 24 h) disodium induces osteoclast apoptosis, which displays characteristics of apoptosis, including chromatin condensation and changed cellular and nuclear morphology, detected by fluorescence microscopy.
  • In Vivo
    ——
  • Synonyms
    Etidronic Acid | Didronel | HEDP | Hydroxyethylidene Diphosphonic Acid
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Tyrosinase
  • Recptor
    protein tyrosine phosphatase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    7414-83-7
  • Formula Weight
    249.99
  • Molecular Formula
    C2H6Na2O7P2
  • Purity
    >98% (HPLC)
  • Solubility
    Water: 11.5 mg/mL
  • SMILES
    CC(O)(P(O)(O)=O)P(O)(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Grases F, et al. Circ J. 2007 Jul; 71(7):1152-6.
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