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Aβ polymerization stimulator O4
CAS No. 71939-12-3
Aβ polymerization stimulator O4( O4 | O-4 | O 4 )
Catalog No. M15751 CAS No. 71939-12-3
Aβ polymerization stimulator O4 is an orcein-related small molecule can drive polymerization of amyloid-β (Aβ).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAβ polymerization stimulator O4
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NoteResearch use only, not for human use.
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Brief DescriptionAβ polymerization stimulator O4 is an orcein-related small molecule can drive polymerization of amyloid-β (Aβ).
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DescriptionAβ polymerization stimulator O4 is an orcein-related small molecule can drive polymerization of amyloid-β (Aβ); directly binds to hydrophobic amino acid residues in Aβ peptides and stabilizes the self-assembly of seeding-competent, β-sheet-rich protofibrils and fibrils, efficiently decreases the concentration of small, toxic Aβ oligomers in complex, heterogeneous aggregation reactions; suppresses inhibition of long-term potentiation by Aβ oligomers in hippocampal brain slices.
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In Vitro——
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In Vivo——
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SynonymsO4 | O-4 | O 4
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PathwayOthers
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TargetAmyloids
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RecptorAmyloids
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Research Area——
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Indication——
Chemical Information
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CAS Number71939-12-3
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Formula Weight429.384
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Molecular FormulaC24H15NO7
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C=C2NC3=C(C(C4=CC=C(O)C=C4O)=C(O)C=C3)OC2=CC1C5=CC=C(O)C=C5O
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Chemical Name2,8-bis(2,4-dihydroxyphenyl)-7-hydroxy-3H-phenoxazin-3-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bieschke J, et al. Nat Chem Biol. 2011 Nov 20;8(1):93-101.
2. Sun Y, et al. J Phys Chem B. 2015 Feb 19;119(7):2786-94.
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