ML141( CID2950007 )

Catalog No. M15727 CAS No. 71203-35-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

ML141
Note

Research use only, not for human use.
Brief Description

ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.
Description

ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.
In Vitro

ML141 (CID-2950007) is not cytotoxic in either cell line at doses of 0.1-3 μM after treatment for 4 days. OVCA429 cells were insensitive to 10 μM compound, whereas some cytotoxicity was observed in SKOV3ip cells at this concentration after a 4-day treatment, although it did not reach statistical significance. ML141 is not cytotoxic toward Swiss 3T3 or Vero E6 cells up to 10 μM for 24 and 48 h, respectively. ML141 inhibits 3T3 fibroblast filopodia formation and inhibits ovarian cancer cell migration.
In Vivo

ML141 (CID-2950007) (10 μM; intracerebroventricular injection) causes acute anxiety in mice. Animal Model:C57Bl/6J mice Dosage:10 μM Administration:Intracerebroventricular injection Result:Increased anxiety in mice.
Synonyms

CID2950007
Pathway

Angiogenesis
Target

CDK
Recptor

cdc42
Research Area

Cancer
Indication

——

CAS Number

71203-35-5
Formula Weight

407.49
Molecular Formula

C22H21N3O3S
Purity

>98% (HPLC)
Solubility

DMSO: 81 mg/mL warmed (198.77 mM)
SMILES

O=S(C1=CC=C(N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)C=C1)(N)=O
Chemical Name

4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide

1. Chen HY, et al. EMBO Mol Med. 2013, 5(5), 723-736.

Calculator

molnova catalog