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JNJ-7706621

CAS No. 443797-96-4

JNJ-7706621( JNJ7706621 | JNJ 7706621 )

Catalog No. M14517 CAS No. 443797-96-4

A dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively; also exhibits activity towards CDK3, CDK4, and CDK6 (IC50s=50-250 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JNJ-7706621
  • Note
    Research use only, not for human use.
  • Brief Description
    A dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively; also exhibits activity towards CDK3, CDK4, and CDK6 (IC50s=50-250 nM).
  • Description
    A dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively; also exhibits activity towards CDK3, CDK4, and CDK6 (IC50s=50-250 nM), and no activity for Plk1 or Wee1; arrests the cell cycle at the G2-M phase; shows significant antitumor activity in tumor xenograft model.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    JNJ7706621 | JNJ 7706621
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    AuroraA|AuroraB|CDK1/CyclinB|CDK2/CyclinA|CDK2/CyclinE
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    443797-96-4
  • Formula Weight
    394.356
  • Molecular Formula
    C15H12F2N6O3S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=S(C1=CC=C(NC2=NN(C(C3=C(F)C=CC=C3F)=O)C(N)=N2)C=C1)(N)=O
  • Chemical Name
    Benzenesulfonamide, 4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Emanuel S, et al. Cancer Res. 2005 Oct 1;65(19):9038-46. 2. Huang S, et al. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3639-41. 3. Seamon JA, et al. Mol Cancer Ther. 2006 Oct;5(10):2459-67.
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