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Bay K-8644
CAS No. 71145-03-4
Bay K-8644( Bay K8644 )
Catalog No. M15726 CAS No. 71145-03-4
Bay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 46 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 122 | In Stock |
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| 25MG | 250 | In Stock |
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| 50MG | 387 | In Stock |
|
| 100MG | 575 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBay K-8644
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NoteResearch use only, not for human use.
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Brief DescriptionBay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM.
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DescriptionBay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM, has positive inotropic, vasoconstrictive and behavioral effects in vivo; enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts (MEFs) to induce pluripotent stem cells (iPSCs) combination with BIX-01294.
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In VitroIn newborn rat ventricular cardiomyocytes, Bay K 8644 (1 μM) treatment increases L-type calcium current density in 2-day-old cells. The higher increase of L-type calcium current density by Bay K 8644 in 2-day- than in 7-day-old cultured cells could be interpreted as the result of a difference in the phosphorylation level of calcium channels for each stage of development.
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In VivoA one time dose as low as 10 μg/kg of Bay K 8644 significantly elevates mean arterial pressure (MAP) in endotoxin-treated hypotensive rats while having minimal effects in normal rats. Bay K 8644 also causes a dose-dependent decrease in heart rate of 37% in endotoxin-treated rats and 39% in control rats.
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SynonymsBay K8644
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorL-type calcium channel
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number71145-03-4
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Formula Weight356.3
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Molecular FormulaC16H15F3N2O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (233.88 mM)
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SMILESO=C(C1=C(C)NC(C)=C([N+]([O-])=O)C1C2=CC=CC=C2C(F)(F)F)OC
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Chemical Name1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang W, et al. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1427-32.
2. Greenberg DA, et al. Brain Res. 1984 Jul 9;305(2):365-8.
3. Bourson A, et al. Eur J Pharmacol. 1989 Feb 7;160(3):339-47.
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